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Diabetic peripheral polyneuropathy (DPNP) is the most common microvascular complication and an amputation risk factor in patients with diabetes. Therefore, early recognition and appropriate management of DPNP are important. Unfortunately, methods for DPNP detection are underutilized in primary-care practice and DPNP is underdiagnosed. To confirm the diagnosis, a nerve-conduction study or skin biopsy is required. However, these procedures are invasive and may be unsuitable for use in clinical practice. The identification of potential patients with DPNP, particularly by non-specialists, requires easily applicable and clinically reliable screening and diagnostic methods. Read More
Condom catheters are widely used in the management of male urinary incontinence, bedridden patient and geriatric population. They are considered to be safe, however, they are associated with complications in care of an incorrect use. In our hospital setup a 73-year-old male bedridden patient attended the surgical opd with complain of penile skin erosion following condom catheter application for 4 days for which dressing was done to remove the slough for 2 days then circumcision was done. Henceforth, although a less known complications are associated with the condom catheter but if not attended promptly can lead to a grave condition like penile gangrene, necrosis, death. Read More
By incorporating a gene-suppressing drug into an over-the-counter gel, researchers at Albert Einstein College of Medicine and their colleagues cut healing time by half and significantly improved healing outcomes compared to control treatments. Results from the combination therapy, which was tested in mice, were published online today in Advances in Wound Care. "Not only did wound healing occur more rapidly and completely, but actual regeneration occurred, with hair follicles and the skin's supportive collagen network restored in wounded skin—clinically important improvements that are unprecedented in wound care," says senior author David J. Sharp, Ph.D, professor of physiology & biophysics at Einstein. "We foresee this therapy having broad application for all sorts of wounds, from playground cuts to battlefield injuries to chronic wounds. Read More
Ever wonder why things that normally feel gentle, like putting on soft shirts, are painful after a sunburn? In a study of four patients with a rare genetic disorder, NIH researchers found that PIEZO2, a gene previously shown to control our sense of our bodies in space and gentle touch, may also be responsible for tactile allodynia: the skin's reaction to injury that makes normally gentle touches feel painful. This and a second NIH-funded study, both published in Science Translational Medicine, used mice to show how the gene may play an essential role in the nervous system's reaction to injury and inflammation, making PIEZO2 a target for developing precise treatments for relieving the pain caused by cuts, burns, and other skin injuries. Read More