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This is the first-time scientists have reported a biological mechanism to explain why some marijuana users have reported beneficial effects from cannabis on intestine inflammation conditions such as ulcerative colitis and Crohn's disease. Researchers hope that their findings will lead to the development of drugs and treatments for gut disorders, which affect millions of people around the world and are caused when the body's immune defenses mistakenly attack the lining of the intestine. Read More
The innate immune system is responsible for responding to infections, clearing cancerous cells, healing wounds, and removing foreign substances. Although many of these functions happen simultaneously in life, most laboratory studies of the innate (or early) immune response focus on one activity. How the innate immune system responds to concurrent insults in different parts of the body is not well understood. To address this question, Dr. Meredith Crane, Dr. Amanda Jamieson and colleagues set out to determine the impact of a respiratory infection on wound healing. Read More
Cilostazol improved amputation-free survival and ulcer healing in patients with critical limb ischemia who underwent endovascular or surgical revascularization, researchers reported. The researchers conducted a retrospective, single-center cohort study to determine predictors of ulcer healing time and amputation-free survival in patients with Rutherford class 5 CLI who underwent infrainguinal arterial revascularization. Read More
Routinely cleansing wounds at every dressing change can do more harm than good, as scrubbing the granulating wound bed with gauze swabs may disrupt fragile tissue growth and damage new capillaries. The body may perceive this as a new injury and re-launch an inflammatory response, which will only delay the healing process. Cleansing wounds is, therefore, not recommended unless the wound shows signs of infection, presents with slough or is visibly contaminated with faecal material or debris. This article explains the circumstances in which it is appropriate to cleanse a wound, when it is appropriate to use tap water and when a sterile solution is recommended. Read More