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The systemic administration of collagen VII protein can reduce bacteria in the skin of mice with epidermolysis bullosa (EB), according to a report published in the journal Proceedings of the National Academy of Sciences. The study, “Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa,” showed that collagen VII is required in the spleen to support the activity of immune cells and promote their innate defense mechanisms. This finding may help researchers understand why people with epidermolysis bullosa, a rare genetic disease caused by a mutation in the COL7A1 gene — which provides instructions for the protein collagen VII — are more susceptible to developing wound infections. The results may also open new therapeutic avenues to treat EB. Read More
Diabetes patients have an increased risk of suffering serious infections or death compared to the general public, new research has shown. The study analysed the electronic GP and hospital records of more than 100,000 adults aged 40 to 89 years with a diabetes diagnosis, and compared them to those without a diabetes diagnosis. The researchers estimated that 6% of infection-related hospital admissions, such as for pneumonia, and 12% of infection-related deaths among adults could be attributed to diabetes. Read More
Iranian scientists have managed to produce an artificial vessel and a type of wound care dressing using polymeric materials. The two technological developments were unveiled in a ceremony attended by the Head of Iran Polymer and Petrochemical Institute (IPPI) Mehdi Nekouhesh. The polymer wound care dressing was invented as part of larger plan to find a treatment for a particular type of skin wounds, a Farsi report by Mehr said. The artificial vessel was the second invention of the Institute’s scientists. The vessel, which is now at the clinical stage, used to be an imported good and is being produced for the first time by IPPI in Iran. Read More
Drug-resistant bacteria are thwarting the world’s last-resort antibiotics, leading scientists to seek new compounds from poisonous frogs, backyard soil bacteria, and other wildlife. Now, scientists have found the makings of an exceptional microbe killer inside us: By tweaking a naturally occurring peptide—a short chain of amino acids—found in the human body, researchers have designed a drug that could wipe out obstinate microbes resistant to all available treatments. When a small subset of bacteria survives antibiotic treatment, an infection can get out of control fast. As these resilient microbes thrive, they can group together on a surface—like a wound or a medical device—and encase themselves in a slimy protective layer known as a biofilm. Read More