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Featured Articles

  • July 16, 2019

    Late Irrigation, Debridement of Open Fractures Did Not Increase Re-Operation Rates

    Irrigation and debridement performed more than 6 hours after the occurrence of an open fracture did not increase the risk of re-operation, based on research presented at a meeting. “The old dogma that open fractures need to be addressed within 6 hours of injury needs to be revisited,” Herman Johal, MD, orthopedic traumatologist and clinical scholar with the Centre for Evidence-Based Orthopaedics (CEO) and department of surgery at McMaster University in Hamilton, Ontario, told Orthopedics Today. Read More  

    Detecting Pressure Ulcers in Sweat and Sebum

    Pressure ulcers are a major burden to patients, carers and the healthcare system. Particularly vulnerable populations are elderly, bedridden and spinal cord injured individuals. Ph.D. researcher Jibbe Soetens investigated the response of the human skin to prolonged loading. Hospitals can use his results to detect and even predict pressure ulcers. Also the design of, for example, mattresses and wheelchairs can be improved with his findings. Read More

    Pilot Study Finds Collagen to Be Effective in Wound Closure

    Collagen powder is just as effective in managing skin biopsy wounds as primary closure with non-absorbable sutures, according to a first-of-its-kind study published in the Journal of Drugs in Dermatology by a team of physician researchers at the George Washington University. The team investigated the efficacy of topical collagen powder compared to primary closure on the rate and quality of full-thickness wound healing through histopathological analysis of healing and comparison of symptoms and early cosmetic outcomes.  Read More

    New Tool Predicts How Electrical Stimulation Promotes Healing

    Scientists have known for decades that electrical stimulation promotes healing of chronic wounds, such as diabetic ulcers and bedsores, but how it happens has been a mystery—until now. "Electrical stimulation is directing the cells to promote migration toward the center of the wound," said Assistant Professor Mark Messerli of the South Dakota State University Department of Biology and Microbiology in the College of Natural Sciences. Messerli and his team developed a tool that predicts how cellular migration and alignment happens.  Read More

  • July 9, 2019

    Diabetic Foot Ulcer Outcomes Improve With Better Access, More Comprehensive Care

    Fewer first-time diabetic foot ulcers were reported from 2013 to 2017 compared with 2003 to 2007 in a high-risk population that had access to more comprehensive podiatry care services, according to findings published in Diabetic Medicine. “Persons living with diabetes and loss of protective foot sensation, foot deformity and/or peripheral vascular disease are at high risk of diabetic foot ulceration, and those with previous ulceration are at even greater risk,” Richard B. Paisey, MD, of the Torbay and South Devon Integrated Care Trust in the United Kingdom, and colleagues wrote. “Attempts to reduce new and recurrent ulceration in high-risk persons have required intensive intervention and follow-up.” Read More  

    Inpatient Hypoglycemia Predicts Major Amputation in Diabetic Foot Disease

    Patients hospitalized with acute diabetic foot are more likely to undergo any or major amputations when experiencing a hypoglycemic event, independent of other amputation risk factors, according to an analysis of electronic medical records data. “This study is the first to assess the impact of glycemic control on patients with acute diabetic foot in the inpatient setting,” Avivit Cahn, MD, a senior physician at Hadassah Hebrew University Medical Center in Jerusalem, told Endocrine Today. “The study found an important association between inpatient glycemic control and amputations, with a stronger association of hypo- rather than hyperglycemia with adverse outcomes.” Read More

    US Study Finds Racial Disparities in Outcomes of Superficial Vein Treatments

    A US-based multicentre study has found that while chronic venous insufficiency is “primarily observed in white women”, there are other notable differences in the incidence and prevalence of disease severity and outcomes when comparing patients’ racial groups, with African Americans requiring a higher number of superficial vein treatments to achieve good results. Peter J Pappas (Center for Vein Restoration, Greenbelt, USA) presented the findings at the European Venous Forum (EVF; 27–29 June) in Zurich, Switzerland. Read More

    Combining Antibiotics, Researchers Deliver One-Two Punch Against Ubiquitouos Bacterium

    By combining two well-established antibiotics for the first time, a scientific team led by Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center has delivered a “double whammy” against the pervasive Pseudomonas aeruginosa, a potentially deadly form of bacteria that is a major source of hospital-based infections. In a recent Journal of Infectious Diseases study, investigators showed using two antibiotic drugs to fight P. aeruginosa in mouse models was significantly more effective than either antibiotic alone. The antibiotics were ceftazidime-avibactam, a combination drug used to treat a wide variety of serious bacterial infections, and fosfomycin, used to primarily treat infections of the urinary tract. Read More

  • July 2, 2019

    Genetic Study Reveals Easily-Exploitable "Chinks in the Armor" of MRSA Superbugs

    Humans are currently locked in an arms race against pathogenic bacteria – and we're losing. After we developed antibiotics, starting with penicillin in the early 20th century, bacteria have evolved resistance to each new drug we created, threatening us with a future where antibiotics simply don't work anymore. Now scientists have identified the genes responsible for antibiotic resistance in a particularly dangerous superbug, and found a way to thwart them. Read More  

    AbbVie to Acquire Allergan for $63 Billion

    Allergan will be acquired by AbbVie for approximately $63 billion in cash and stock, the two companies announced in a press release. Under a definitive transaction agreement, which has been signed by both entities, Allergan shareholders will receive 0.8660 AbbVie shares and $120.30 in cash for each Allergan share they hold. "This acquisition creates compelling value for Allergan's stakeholders, including our customers, patients and shareholders. With 2019 annual combined revenue of approximately $48 billion, scale in more than 175 countries, an industry-leading R&D pipeline and robust cash flows, our combined company will have the opportunity to make even bigger contributions to global health than either can alone," Brent Saunders, Allergan chairman and CEO, said. Read More

    Obesity Increases Risk for Developing SSIs

    Obesity Increases a Patient’s Risk for Developing a Surgical Site Infection, or Ssi, Although the Extent of Impact Depends on the Type of Surgery, According to a Recent Study Conducted in the Netherlands. “the Prevalence of Obesity Is Growing Worldwide and Is Reaching Epidemic Proportions in Developed Countries,” Anouk P. Meijs, Msc, from the Centre for Infectious Disease Control in the Netherlands’ National Institute for Public Health and the Environment, and Colleagues Wrote. Read More

    Skin Shedding May Contribute to Spread of C. Auris

    Patients colonized with Candida auris carry a high burden of the emerging and often multidrug-resistant fungal pathogen on their skin, suggesting that the natural process of skin shedding among these patients leads to contamination of the heath care environment and contributes to transmission, according to findings presented at ASM Microbe. C. auris presents a public health concern because of its ability to cause large and persistent outbreaks, such as the outbreak in New York City hospitals. The specific mechanisms of transmission are not clear, which makes controlling these outbreaks difficult, according to Joe Sexton, PhD, a postdoctoral fellow in the CDC’s Mycotic Diseases Branch, and colleagues. Read More

  • June 25, 2019

    Atopic Dermatitis is Linked to an Increased Risk of Extracutaneous Infections

    “We have known for a long time that atopic dermatitis [AD] is associated with increased skin infections for several reasons, such as skin-barrier dysfunction, lower antimicrobial peptides, and increased bacterial colonization,” says Jonathan Silverberg, MD, PhD, MPH, director of the Northwestern Medicine Multidisciplinary Eczema Center in Chicago. But the association between AD and extracutaneous infections is not as well understood because studies have reported contrary findings. Read More  

    'Early Warning' Tool for Hard-To-Heal Leg Wounds

    Some 500,000 Australians live with the daily burden of a wound that does not heal, but a risk assessment tool that provides an 'early warning' of which venous leg ulcer wounds need specialized treatment has been developed by QUT's Dr Christina Parker. Dr. Parker's presentation on the assessment tool and its potential to help curb the $4 billion annual cost of treating chronic wounds received the top award at the CRC Association Collaborate Innovate 2019 Conference last week. "The tool is simple," Dr. Parker, from QUT's Institute of Health and Biomedical Innovation, said. Read More

    Hydrogel Offers Double Punch Against Orthopedic Bone Infections

    Surgery prompted by automobile accidents, combat wounds, cancer treatment and other conditions can lead to bone infections that are difficult to treat and can delay healing until they are resolved. Now, researchers have a developed a double-duty hydrogel that both attacks the bacteria and encourages bone regrowth with a single application containing two active components. The injectable hydrogel, which is a network of cross-linked polymer chains, contains the enzyme lysostaphin and the bone-regenerating protein BMP-2. Read More

    Manuka Honey to Kill Drug-Resistant Bacteria Found in Cystic Fibrosis Infections 

    Dr. Rowena Jenkins and Dr. Aled Roberts have found that using Manuka honey could offer an antibiotic alternative to treat antimicrobial resistant respiratory infections, particularly deadly bacteria found in Cystic Fibrosis (CF) infections. Using lung tissue from pigs, experts treated grown bacterial infections mimicking those seen in CF patients with Manuka honey. Read More

  • June 18, 2019

    Risk for Kidney Transplant Failure Quintuples with Postsurgical Diabetic Foot Ulcer

    Kidney transplantation is more likely to fail for adults with diabetic kidney disease and diabetic neuropathy who then present with a diabetic foot ulcer after surgery vs. those without foot ulcer, according to findings presented at the American Diabetes Association 79th Scientific Sessions. In addition, common factors for post-transplant diabetic foot ulcers include a prior history of the condition as well as previous peripheral arterial disease. Read More  

    Rosacea, Other ‘Mimic’ Skin Conditions Often Misdiagnosed as Rheumatic Diseases

    Patients with rosacea, livedoid vasculopathy and allergic contact dermatitis present with a multitude of dermatologic symptoms that rheumatologists can easily misdiagnose as rheumatic diseases, according to Anthony Fernandez, MD, PhD, of the Cleveland Clinic. However, he noted that rheumatologists can distinguish these dermatological conditions from their common rheumatic lookalikes — acute lupus, vasculitis and dermatomyositis — by paying attention to onset timing, chronicity and their associated symptoms. Read More

    Reimagined Hospital Bed Minimizes Risk of Pressure Ulcers

    Electrical engineering students in Arizona State University’s Ira A. Fulton Schools of Engineering completed their final capstone course with a bang. And for one team, it also ended with an award and the reward of carrying out a project that makes a difference for patients staying in hospitals. Seniors worked on a two-semester design project to fulfill all of the academic requirements for a bachelor’s degree in electrical engineering while gaining experience to prepare for the workplace. Read More

    Salamanders May Help Wound Healing: Goo Secreted by the Amphibians Sticks Injured Tissue Back Together Better Than 'Most Medical Adhesives' 

    A 'goo' given off by salamanders could revolutionize wound healing by replacing existing surgical glues. A study found the skin secretions of Chinese giant salamanders, the world's largest and longest-living amphibian, enables injured tissues to 'stick' together better than an existing 'natural' adhesive. The animals' mucus also improves skin elasticity, reduces scarring and eases side effects more than a 'chemical' glue that is currently used to repair wounds. Read More

  • June 12, 2019

    Top 7 Reasons Pressure Ulcer Rates are Still Going Up in Hospitals

    From 2014 to 2017, the overall rate of HACs had declined by 13%. Per AHRQ, 20,500 lives have been saved in that period, along with $7.7 billion in avoidable healthcare costs. In looking closer at the data, however, the rates for Pressure Injuries (PIs, also commonly referred to as Pressure Ulcers or Bed Sores) actually increased by 6% during that period. It was the only category of HACs measured that had gone up. Read More  

    Nanoscale Bioabsorbable Wound Dressing

    Scientists are harnessing the combined power of organic nanomaterials-based chemistry and a natural product found in crustacean exoskeletons to help bring emergency medicine one step closer to a viable solution for mitigating blood loss, from the hospital to the battlefield. Read More

    Atopic Dermatitis in Adults Associated with Increased Risk of Dementia

    Atopic dermatitis in adulthood was associated with a twofold increase in the risk of developing dementia late in life, based on results from a large longitudinal cohort study presented at the annual meeting of the Society for Investigative Dermatology.  Read More

    Molecular Bait Can Help Hydrogels Heal Wounds 

    Bioengineers develop modular, injectable hydrogels enhanced by bioactive molecules anchored in the chemical crosslinkers that give the gels structure. The hydrogels can be mixed at room temperature and customized to help heal a variety of wounds.  Read More