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Featured Articles

  • June 19, 2018

    Machine Learning Identifies Lymphedema in Breast Cancer Survivors with 94% Accuracy

    Researchers from the New York University Rory Meyers College of Nursing have found machine learning using real-time symptom reports to be accurate in identifying lymphedema early in breast cancer patients. Clinicians often detect or diagnose lymphedema based on their observation of swelling. However, by the time swelling can be observed or measured, lymphedema has typically occurred for some time, which may lead to poor clinical outcomes. Read More

    FDA Issues Guidance on Drugs to Treat Epidermolysis Bullosa

    The US Food and Drug Administration (FDA) on Friday released a draft guidance aimed at helping sponsors develop drugs to treat epidermolysis bullosa (EB), a group of genetic disorders that cause fragile skin and blistering. FDA says it is developing the guidance to help address the "paucity of effective treatment options" for the disease, as there are no available treatments that cure EB. Instead, the standard of care for EB focuses on wound care and pain management. Read More

    This Handheld Device Could Print New Skin on to Burn Victims

    A patient with severe burn injuries is brought to a burn center, in need of a skin graft immediately. A surgeon comes in with a small, handheld device and quickly dispenses thin sheets of artificial skin onto the wounds as easily as rolling out Scotch tape. This scenario could become reality, thanks to a new device developed by Canadian scientists: a handheld 3D skin printer that deposits layers of skin tissue on burns and other injuries. Read More

    Constructing New Tissue Shapes With Light

    Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer. Researchers have succeeded in guiding the folding and thus shape of tissues with optogenetics: a technique to control protein activity with light. The changing of tissue shapes in an embryo is essential for healthy development. Stefano De Renzis and his group members at EMBL are interested in the mechanisms behind these shape transitions, also called morphogenesis. Read More

     

  • June 12, 2018

    Cellulitis and Soft Tissue Infections

    Cellulitis and soft tissue infections are a diverse group of diseases that range from uncomplicated cellulitis to necrotizing fasciitis. Management of predisposing conditions is the primary means of prevention. Cellulitis is a clinical diagnosis and thus is made on the basis of history and physical examination. Imaging may be helpful for characterizing purulent soft tissue infections and associated osteomyelitis. Read More

    Iclaprim Found to be Effective and Safe Treatment for Acute Bacterial Skin and Skin Structure Infections

    Pooled analyses of 2 phase 3 trials have conclusively established the safety and effectiveness of iclaprim compared to vancomycin in the treatment of acute bacterial skin and skin structure infections (ABSSSI). The results cap the efforts needed for an approval application to the US Food and Drug Administration which is slated to happen within weeks. Read More

    Dressed for Success

    Wound care dressing options have exploded, but deciding which material is best for which injury sometimes is an elusive quest for providers. No more. A good basic wound care formulary should provide the treatment nurse with a variety of tools, including wound cleanser, periwound skin prep, and dressings to support wound healing throughout the continuum, from dry to heavily draining wounds and those with bioburden or infection. Read More

    Blood Sugar Control Doesn't Improve Diabetic Foot Ulcers

    Having a healthy baseline HbA1c reading or improving blood glucose levels did not improve wound healing time among patients with diabetic foot ulcers, according to a new observational study. Though chronically high blood glucose levels are known harbingers of wound development, bringing those levels under control didn't speed up healing among 270 patients seen at the Johns Hopkins Multidisciplinary Diabetic Foot and Wound Clinic over a five-year period. Read More

     

  • June 5, 2018

    WOCN Society's 50th Annual Conference - June 3-6, 2018 - Philadelphia, PA

    Disseminate research and evidence-based knowledge of the latest techniques, applications, technologies and treatments related to wound, ostomy and continence issues to impact patient outcomes. Read More

    Variation is the Enemy of Quality in CLI Treatment

    Critical limb ischemia presents tremendous challenges that cannot be neglected or ignored. It is associated with incredibly high rates of morbidity and mortality. Clearly, the medical system is not adequately addressing the needs of these patients. I suggest that some of the flaws in the way we care for patients with CLI are emblematic of larger flaws in the U.S. health care system, and that an emphasis on consistency and team-based care may lead to improvements for these patients and our system. Read More

    Origami Inspires Researchers to Develop New Solution for Tissue Regeneration

    Origami - the Japanese art of folding paper into shapes and figures - dates back to the sixth century. At UMass Lowell, it is inspiring researchers as they develop a 21st century solution to the shortage of tissue and organ donors. Gulden Camci-Unal, an assistant professor of chemical engineering, and her team of student researchers are designing new biomaterials that could someday be used to repair, replace or regenerate skin, bone, cartilage, heart valves, heart muscle and blood vessels, and in other applications. Read More

    Healogics Shines a Light on Chronic Wounds with Fifth Annual Wound Care Awareness Week

    Healogics, Inc., the nation's leading provider of advanced wound care services, is proud to sponsor the fifth annual Wound Care Awareness Week from June 4 to June 8, 2018. Throughout this week, Healogics team members from around the country will be working together to shed light on the chronic wound epidemic and bring awareness to the advanced wound care options available. Unfortunately, the incidence of chronic wounds is only expected to rise over the next decade, making awareness and advanced wound care more important now than ever before. Read More

    New Nanoparticles Help to Detect Serious Scarring of Wounds

    Clinicians currently find it difficult to predict how scars will develop following surgery or after a burn wound, without resorting to invasive testing. Using new nanoparticles, the joint research team has shown in animals and human skin samples the potential to quickly and accurately predict whether a wound is likely to lead to excessive scarring as occurs in keloids and skin contractures. Read More

  • May 22, 2018

    Nutrition Can Aid in Healing Diabetic Foot Ulcers

    Nutrition is a critical component of healing diabetic foot ulcers, particularly as it relates to immune function, malnutrition, glycemic control, and weight loss and weight maintenance. Diabetes educators should include nutrition assessment and intervention as key components of the overall diabetes treatment plan to help patients with diabetic foot ulcers maximize their nutritional status and promote wound healing. Read More

    Molecular Study of Wound Healing After Using Biosynthesized BNC/Fe3O4

    Molecular investigation of wound healing has allowed better understanding about interaction of genes and pathways involved in healing progression. The aim of this study was to prepare magnetic/bacterial nanocellulose (Fe3O4/BNC) nanocomposite films as ecofriendly wound dressing in order to evaluate their physical, cytotoxicity and antimicrobial properties. The molecular study was carried out to evaluate expression of genes involved in healing of wounds after treatment with BNC/Fe3O4 films. Read More

    Protein Discovery Could Lead to Wound Healing Treatments in People With Diabetes

    A particular protein that affects the healing of foot and lower leg wounds in people with diabetes has been identified by US researchers. The thrombospondin-2 (TSP2) protein could be targeted to improve treatment for foot ulcers and aid wound healing, researchers say. TSP2 is an integral part of what is known as the extracellular matrix, which behaves like scaffolding in the development of cells. TSP2 is involved in how cells grow, and the research shows that it is a factor that affects how well wounds heal. Read More

    Early Endovenous Ablation Beneficial in Patients with Leg Ulcers

    Compared with delayed ablation, early endovenous ablation conferred faster healing from leg ulcers due to venous disease and more time free from ulcers, according to findings presented at the Charing Cross International Symposium and published in The New England Journal of Medicine. For the EVRA trial, researchers randomly assigned 450 patients with venous ulcers in the leg to compression therapy and to undergo early endovenous ablation of superficial venous reflux within 2 weeks of randomization or to compression therapy alone with endovenous ablation deferred until the ulcer was healed or after 6 months. The primary outcome was time to ulcer healing.  Read More

  • May 15, 2018

    Nutrition in Patients with Chronic Non-Healing Ulcers: a Paradigm Shift in Wound Care

    Chronic ulcers continue to pose a significant clinical and economic burden for both patients and wound care practitioners. Despite good standard of care (SOC), many wounds fail to heal. Wound healing requires a complex cascade of physiologic and immunologic processes as well as proper nutrition. An adequate balance of macro- and micronutrients is important to support the cellular activities that are necessary for repairing and remodeling of tissue. Despite being well documented in a number of clinical studies there continues to be a gap in recognizing nutritional deficits as well as appropriate clinical interventions in patients with chronic wounds. Read More

    Study Shows Safety, Efficacy of Stem Cells in Treating Angiitis-Induced Critical Limb Ischemia

    A long-term study of patients who received stem cells to treat angiitis-induced critical limb ischemia (AICLI) shows the cells to be both safe and effective. The study, published in STEM CELLS Translational Medicine (SCTM), could lead to an option for those who suffer from this serious form of peripheral arterial disease (PAD). AICLI is caused by an inflammation of the blood vessels that leads to a severe blockage in the arteries of the lower or upper extremities. It causes severe pain and impaired mobility, and can even lead to amputation and death. While endovascular and surgical reconstruction are the mainstream treatments for critical limb ischemia (CLI), these classical treatments are unfeasible in approximately 15 to 20 percent of patients. Read More

    HbA1c, Wound Healing Unrelated in Diabetic Foot Ulcers

    Among patients with long-term diabetic foot ulcers, neither baseline HbA1c nor change in HbA1c was associated with wound healing time, according to findings from a clinic-based observational study. “Although we know that chronic hyperglycemia leads to neuropathy and peripheral vascular disease, which are the proximal risk factors for diabetic foot ulcers, we did not see a clear association between HbA1c levels and wound healing in patients who have developed foot ulcers.” Read More

    Making Sense Out of Quality Measures in Long-Term Care

    What are the quality measures that are most important, he asked — particularly from the perspective of the physical therapist? And if there are options between two interventions, Ciolek asked, how does long-term care work with the government to develop measures that help determine what care is most appropriate, along with educating frontline clinicians to understand and address resident needs? “As clinicians, we may develop a narrow-minded standpoint of looking on with blinders and focusing on the ability of a person to move their legs or walk,” he said. “But the broader perspective is how does that affect their whole quality of life and their ability to function safely wherever they may live? What haven't we addressed?” Read More

  • May 8, 2018

    Flesh-eating Bacteria: Terrifying, but Rare Condition

    The term “flesh-eating bacteria” is misleading since it’s a disease, not a particular bacteria species. The term refers to a condition called “necrotizing fasciitis” (“necrotizing” means that the infection kills cells, and “fasciitis” references the connective tissue in the body that the infection proceeds along). However terrifying, it is fortunately a rare condition. There are only about 1-3 cases per 100,000 people. It may occur in people who are otherwise healthy and who happen to get an injury that penetrates the skin. Read More

    No Link Between HbA1c Levels and Wound Healing in Patients With Diabetic Foot Ulcers

    There does not appear to be an association between baseline and prospective hemoglobin A1c (HbA1c) levels on wound healing in patients diagnosed with diabetic foot ulcers, according to a study published in Diabetes Care. Researchers performed a retrospective analysis of an ongoing prospective, clinic-based observational study of patients diagnosed with diabetic foot ulcers being treated at the Johns Hopkins Multidisciplinary Diabetic Foot and Wound Clinic in Baltimore, Maryland, over the course of 4.7 years. Read More

    Skin Cancer Symptoms: Four Skin Conditions That Raise Your Risk of Developing the Disease

    SKIN cancer symptoms can include a new mole or a change in an existing mole. UV exposure is the main preventable cause of the disease, and wearing sunscreen can help keep you safe in the sun. But there are four skin conditions that can put you more at risk of developing the disease. Read More

    Leg Ulcers from Venous Insufficiency Heal Faster with Early Ablation

    Good results were seen when venous disease causing leg ulceration was treated with early endovenous ablation of superficial venous reflux as an adjunct to compression therapy, investigators reported. Patients had their leg ulcers heal faster if they got compression therapy and were randomized to endovenous ablation of the reflux within 2 weeks instead of waiting to ablate until after the ulcer was healed or 6 months had passed (healing time 56 days versus 82 days, adjusted HR 1.42, 95% CI 1.16 to 1.73), according to Alun Davies, DSc, of Cambridge University Hospitals NHS Foundation Trust in England, and colleagues. Read More